Assay Detail
Binding
CHEMBL995853
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Binding affinity to mu opioid receptor
9
Total Activities
9
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Publication
Nitrile analogs of meperidine as high affinity and selective sigma-1 receptor ligands.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 9 | 5.12 | 5.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL495549 | — | — | 1 | 5.23 |
| CHEMBL495760 | — | — | 1 | 5.01 |
| CHEMBL495954 | — | — | 1 | - |
| CHEMBL502461 | — | — | 1 | - |
| CHEMBL495759 | — | — | 1 | - |
| CHEMBL486190 | — | — | 1 | - |
| CHEMBL495548 | — | — | 1 | - |
| CHEMBL473112 | — | — | 1 | - |
| CHEMBL495955 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL495549 | — | Ki | = | 5900.0 | nM | 5.23 |
| CHEMBL495760 | — | Ki | = | 9800.0 | nM | 5.01 |
| CHEMBL495954 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL502461 | — | Ki | - | — | - | |
| CHEMBL495759 | — | Ki | - | — | - | |
| CHEMBL486190 | — | Ki | - | — | - | |
| CHEMBL495548 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL473112 | — | Ki | - | — | - | |
| CHEMBL495955 | — | Ki | > | 10000.0 | nM | - |