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Assay Detail

CHEMBL996056

Review assay metadata, readout intent, target linkage, and publication context from the same page.

ADMET
Inhibition of CYP3A4
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type ADMET
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Cytochrome P450 3A4 (CHEMBL340)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.
Jin J, Wang Y, Shi D, Wang F, Davis RS, Jin Q, Fu W, Foley JJ, Webb EF, Dehaas CJ, Berlanga M, Burman M, Sarau HM, Morrow DM, Rao P, Kallal LA, Moore ML, Rivero RA, Palovich M, Salmon M, Belmonte KE, Busch-Petersen J.
J Med Chem (2008) 51 : 4866 -4869
PubMed 18680280 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 5.00 5.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL540359 1 5.00

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL540359 IC50 = 10000.0 nM 5.00