Assay Detail
Functional
CHEMBL996726
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Agonist activity at rat androgen receptor expressed in mouse skeletal muscle C2C12 cells assessed as transcriptional activation after 24 hrs by androgen-specific response element driven luciferase reporter gene assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | C2C12 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
N-aryl-oxazolidin-2-imine muscle selective androgen receptor modulators enhance potency through pharmacophore reorientation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 13 | 8.19 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL484726 | — | — | 1 | 9.70 |
| CHEMBL521329 | — | — | 1 | 8.96 |
| CHEMBL484728 | — | — | 1 | 8.85 |
| CHEMBL229861 | — | — | 1 | 8.74 |
| CHEMBL483745 | — | — | 1 | 8.43 |
| CHEMBL484919 | — | — | 1 | 8.32 |
| CHEMBL229860 | — | — | 1 | 8.27 |
| CHEMBL229808 | — | — | 1 | 8.19 |
| CHEMBL229264 | — | — | 1 | 8.11 |
| CHEMBL520174 | — | — | 1 | 7.85 |
| CHEMBL484727 | — | — | 1 | 7.72 |
| CHEMBL519169 | — | — | 1 | 7.36 |
| CHEMBL482549 | — | — | 1 | 5.96 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL484726 | — | EC50 | = | 0.2 | nM | 9.70 |
| CHEMBL521329 | — | EC50 | = | 1.1 | nM | 8.96 |
| CHEMBL484728 | — | EC50 | = | 1.4 | nM | 8.85 |
| CHEMBL229861 | — | EC50 | = | 1.8 | nM | 8.74 |
| CHEMBL483745 | — | EC50 | = | 3.7 | nM | 8.43 |
| CHEMBL484919 | — | EC50 | = | 4.8 | nM | 8.32 |
| CHEMBL229860 | — | EC50 | = | 5.4 | nM | 8.27 |
| CHEMBL229808 | — | EC50 | = | 6.4 | nM | 8.19 |
| CHEMBL229264 | — | EC50 | = | 7.8 | nM | 8.11 |
| CHEMBL520174 | — | EC50 | = | 14.0 | nM | 7.85 |
| CHEMBL484727 | — | EC50 | = | 19.0 | nM | 7.72 |
| CHEMBL519169 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL482549 | — | EC50 | = | 1109.0 | nM | 5.96 |