Assay Detail
Binding
CHEMBL996841
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Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease patient brain homogenate
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Tissue | Brain |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Synthesis and evaluation of 18F-labeled 2-phenylbenzothiazoles as positron emission tomography imaging agents for amyloid plaques in Alzheimer's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 6 | 7.84 | 8.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL490083 | — | — | 1 | 8.66 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | 2.0 | 1 | 8.55 |
| CHEMBL510384 | — | — | 1 | 8.24 |
| CHEMBL490084 | — | — | 1 | 7.65 |
| CHEMBL490085 | — | — | 1 | 6.11 |
| CHEMBL501127 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL490083 | — | Ki | = | 2.2 | nM | 8.66 |
| CHEMBL207456 | PITTSBURGH COMPOUND B | Ki | = | 2.8 | nM | 8.55 |
| CHEMBL510384 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL490084 | — | Ki | = | 22.5 | nM | 7.65 |
| CHEMBL490085 | — | Ki | = | 776.0 | nM | 6.11 |
| CHEMBL501127 | — | Ki | > | 4000.0 | nM | - |