Compound Detail
CHEMBL490085
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Basic Information
| ChEMBL ID | CHEMBL490085 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OTLZQFQXGJUPOE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
261.3
MW (Da)
3.51
ALogP
4
HBA
2
HBD
53.4
PSA (Ų)
0.70
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 6.11
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Amyloid-beta precursor protein CHEMBL2487 | Ki | 6.11 | 6.11 | 776.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Amyloid-beta precursor protein | Ki | = | 776.0 | nM | 6.11 | Displacement of [125I]IMPY from beta-amyloid plaques in Alzheimer's disease pati... | 19216563 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19216563 | 10.1021/jm8013376 | Amyloid-beta precursor protein | 1 |
| 19216563 | 10.1021/jm8013376 | No relevant target | 1 |
Data from ChEMBL 36 via Core Engine