Assay Detail
Functional
CHEMBL998012
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Agonist activity at UT2 receptor in Albino rat aorta assessed as induction of aortic contraction
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Tissue | Aorta |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
New insight into the binding mode of peptide ligands at Urotensin-II receptor: structure-activity relationships study on P5U and urantide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 11 | 8.37 | 9.60 |
| pEC50 | 1 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL390094 | — | — | 1 | 9.60 |
| CHEMBL504097 | — | — | 1 | 9.18 |
| CHEMBL524855 | — | — | 1 | 8.87 |
| CHEMBL510618 | — | — | 1 | 8.86 |
| CHEMBL426020 | — | — | 1 | 8.60 |
| CHEMBL437430 | HUMAN UROTENSIN II | — | 1 | 8.30 |
| CHEMBL452403 | — | — | 1 | 8.28 |
| CHEMBL501794 | — | — | 1 | 8.22 |
| CHEMBL509604 | — | — | 1 | 8.04 |
| CHEMBL508811 | — | — | 1 | 7.14 |
| CHEMBL505358 | — | — | 1 | 6.99 |
| CHEMBL223905 | URANTIDE | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL390094 | — | EC50 | = | 0.2512 | nM | 9.60 |
| CHEMBL504097 | — | EC50 | = | 0.6607 | nM | 9.18 |
| CHEMBL524855 | — | EC50 | = | 1.349 | nM | 8.87 |
| CHEMBL510618 | — | EC50 | = | 1.38 | nM | 8.86 |
| CHEMBL426020 | — | EC50 | = | 2.512 | nM | 8.60 |
| CHEMBL437430 | HUMAN UROTENSIN II | EC50 | = | 5.012 | nM | 8.30 |
| CHEMBL452403 | — | EC50 | = | 5.248 | nM | 8.28 |
| CHEMBL501794 | — | EC50 | = | 6.026 | nM | 8.22 |
| CHEMBL509604 | — | EC50 | = | 9.12 | nM | 8.04 |
| CHEMBL508811 | — | EC50 | = | 72.44 | nM | 7.14 |
| CHEMBL505358 | — | EC50 | = | 102.33 | nM | 6.99 |
| CHEMBL223905 | URANTIDE | pEC50 | - | — | - |