Assay Detail
ADMET
CHEMBL998739
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Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs by MTT assay
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | ADMET |
| Organism | Mus musculus |
| Cell Type | RAW264.7 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Inhibitory effect of the alkyl side chain of caffeic acid analogues on lipopolysaccharide-induced nitric oxide production in RAW264.7 macrophages.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 25 | 5.35 | 6.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL496598 | — | — | 1 | 6.00 |
| CHEMBL499487 | — | — | 1 | 5.92 |
| CHEMBL524294 | — | — | 1 | 5.90 |
| CHEMBL497285 | — | — | 1 | 5.83 |
| CHEMBL496493 | — | — | 1 | 5.81 |
| CHEMBL450591 | — | — | 1 | 5.80 |
| CHEMBL496492 | — | — | 1 | 5.78 |
| CHEMBL497284 | — | — | 1 | 5.71 |
| CHEMBL452132 | FARNESYL CAFFEATE | — | 1 | 5.58 |
| CHEMBL496662 | HEXYLCAFFEATE | — | 1 | 5.57 |
| CHEMBL471797 | — | — | 1 | 5.57 |
| CHEMBL497457 | GERANYL CAFFEATE | — | 1 | 5.51 |
| CHEMBL498715 | — | — | 1 | 5.50 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | — | 1 | 5.34 |
| CHEMBL118111 | — | — | 1 | 5.34 |
| CHEMBL29489 | BUTYL CAFFEATE | — | 1 | 5.13 |
| CHEMBL503812 | — | — | 1 | 4.89 |
| CHEMBL17362 | — | — | 1 | 4.58 |
| CHEMBL472582 | — | — | 1 | 4.54 |
| CHEMBL471184 | PRENYL CAFFEATE | — | 1 | 4.52 |
| CHEMBL133714 | BENZYL CAFFEATE | — | 1 | 4.41 |
| CHEMBL481890 | — | — | 1 | 4.38 |
| CHEMBL17347 | ETHYL CAFFEATE | — | 1 | - |
| CHEMBL17001 | METHYLCAFFEATE | — | 1 | - |
| CHEMBL145 | CAFFEIC ACID | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL496598 | — | EC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL499487 | — | EC50 | = | 1188.0 | nM | 5.92 |
| CHEMBL524294 | — | EC50 | = | 1256.0 | nM | 5.90 |
| CHEMBL497285 | — | EC50 | = | 1473.0 | nM | 5.83 |
| CHEMBL496493 | — | EC50 | = | 1542.0 | nM | 5.81 |
| CHEMBL450591 | — | EC50 | = | 1588.0 | nM | 5.80 |
| CHEMBL496492 | — | EC50 | = | 1658.0 | nM | 5.78 |
| CHEMBL497284 | — | EC50 | = | 1940.0 | nM | 5.71 |
| CHEMBL452132 | FARNESYL CAFFEATE | EC50 | = | 2658.0 | nM | 5.58 |
| CHEMBL496662 | HEXYLCAFFEATE | EC50 | = | 2677.0 | nM | 5.57 |
| CHEMBL471797 | — | EC50 | = | 2671.0 | nM | 5.57 |
| CHEMBL497457 | GERANYL CAFFEATE | EC50 | = | 3054.0 | nM | 5.51 |
| CHEMBL498715 | — | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL319244 | CAFFEIC ACID PHENETHYL ESTER | EC50 | = | 4518.0 | nM | 5.34 |
| CHEMBL118111 | — | EC50 | = | 4594.0 | nM | 5.34 |
| CHEMBL29489 | BUTYL CAFFEATE | EC50 | = | 7419.0 | nM | 5.13 |
| CHEMBL503812 | — | EC50 | = | 13000.0 | nM | 4.89 |
| CHEMBL17362 | — | EC50 | = | 26420.0 | nM | 4.58 |
| CHEMBL472582 | — | EC50 | = | 28700.0 | nM | 4.54 |
| CHEMBL471184 | PRENYL CAFFEATE | EC50 | = | 30000.0 | nM | 4.52 |
| CHEMBL133714 | BENZYL CAFFEATE | EC50 | = | 38800.0 | nM | 4.41 |
| CHEMBL481890 | — | EC50 | = | 42200.0 | nM | 4.38 |
| CHEMBL17347 | ETHYL CAFFEATE | EC50 | = | 121700.0 | nM | - |
| CHEMBL17001 | METHYLCAFFEATE | EC50 | = | 367500.0 | nM | - |
| CHEMBL145 | CAFFEIC ACID | EC50 | = | 3406000.0 | nM | - |