Compound Detail
CHEMBL497284
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Basic Information
| ChEMBL ID | CHEMBL497284 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WXIIKRNYLFHVHF-WYMLVPIESA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
333.5
MW (Da)
4.76
ALogP
3
HBA
3
HBD
69.6
PSA (Ų)
0.29
QED
0
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.09
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAW264.7 CHEMBL612557 | EC50 | 7.09 | 6.4 | 81.5 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAW264.7 | EC50 | = | 81.51 | nM | 7.09 | Inhibition of LPS-induced nitric oxide production in mouse RAW264.7 cells assess... | 18667320 |
| RAW264.7 | EC50 | = | 1940.0 | nM | 5.71 | Cytotoxicity against mouse RAW264.7 cells assessed as cell survival after 24 hrs... | 18667320 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18667320 | 10.1016/j.bmc.2008.07.006 | RAW264.7 | 2 |
Data from ChEMBL 36 via Core Engine