Assay Detail
Binding
CHEMBL998746
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Inhibition of serotonin uptake at human SERT expressed in HEK293 cells
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Sodium-dependent serotonin transporter (CHEMBL228) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 30 | 5.88 | 7.46 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL524313 | — | — | 1 | 7.46 |
| CHEMBL641 | ATOMOXETINE | 4.0 | 1 | 6.75 |
| CHEMBL444742 | — | — | 1 | 6.52 |
| CHEMBL498482 | — | — | 1 | 6.52 |
| CHEMBL498120 | — | — | 1 | 6.41 |
| CHEMBL448375 | — | — | 1 | 6.30 |
| CHEMBL497846 | — | — | 1 | 6.25 |
| CHEMBL505433 | — | — | 1 | 6.05 |
| CHEMBL526669 | — | — | 1 | 6.02 |
| CHEMBL498495 | — | — | 1 | 5.92 |
| CHEMBL445082 | — | — | 1 | 5.89 |
| CHEMBL525375 | — | — | 1 | 5.85 |
| CHEMBL497479 | — | — | 1 | 5.80 |
| CHEMBL497512 | — | — | 1 | 5.77 |
| CHEMBL498509 | — | — | 1 | 5.68 |
| CHEMBL443952 | — | — | 1 | 5.57 |
| CHEMBL498142 | — | — | 1 | 5.55 |
| CHEMBL497461 | — | — | 1 | 5.52 |
| CHEMBL452429 | — | — | 1 | 5.50 |
| CHEMBL497463 | — | — | 1 | 5.40 |
| CHEMBL524798 | — | — | 1 | 5.40 |
| CHEMBL525717 | — | — | 1 | 5.35 |
| CHEMBL525238 | — | — | 1 | 5.34 |
| CHEMBL498141 | — | — | 1 | 5.17 |
| CHEMBL504606 | — | — | 1 | 5.11 |
| CHEMBL510352 | — | — | 1 | - |
| CHEMBL525532 | — | — | 1 | - |
| CHEMBL498481 | — | — | 1 | - |
| CHEMBL526270 | — | — | 1 | - |
| CHEMBL180101 | ESREBOXETINE | 3.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL524313 | — | IC50 | = | 35.0 | nM | 7.46 |
| CHEMBL641 | ATOMOXETINE | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL444742 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL498482 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL498120 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL448375 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL497846 | — | IC50 | = | 560.0 | nM | 6.25 |
| CHEMBL505433 | — | IC50 | = | 900.0 | nM | 6.05 |
| CHEMBL526669 | — | IC50 | = | 960.0 | nM | 6.02 |
| CHEMBL498495 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL445082 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL525375 | — | IC50 | = | 1400.0 | nM | 5.85 |
| CHEMBL497479 | — | IC50 | = | 1600.0 | nM | 5.80 |
| CHEMBL497512 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL498509 | — | IC50 | = | 2100.0 | nM | 5.68 |
| CHEMBL443952 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL498142 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL497461 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL452429 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL497463 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL524798 | — | IC50 | = | 4000.0 | nM | 5.40 |
| CHEMBL525717 | — | IC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL525238 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL498141 | — | IC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL504606 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL510352 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL525532 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL498481 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL526270 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL180101 | ESREBOXETINE | IC50 | > | 10000.0 | nM | - |