Assay Detail
Binding
CHEMBL998751
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cells
29
Total Activities
29
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | IMR-32 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Corticotropin-releasing factor receptor 1 (CHEMBL1800) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
2-Arylpyrimidines: novel CRF-1 receptor antagonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 29 | 7.57 | 9.70 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL498311 | — | — | 1 | 9.70 |
| CHEMBL1628268 | — | — | 1 | 8.70 |
| CHEMBL524616 | — | — | 1 | 8.70 |
| CHEMBL525716 | — | — | 1 | 8.70 |
| CHEMBL9946 | CP-154526 | — | 1 | 8.52 |
| CHEMBL309138 | — | — | 1 | 8.52 |
| CHEMBL497651 | — | — | 1 | 8.22 |
| CHEMBL438888 | — | — | 1 | 8.22 |
| CHEMBL497652 | — | — | 1 | 8.10 |
| CHEMBL498667 | — | — | 1 | 8.05 |
| CHEMBL497653 | — | — | 1 | 8.05 |
| CHEMBL497301 | — | — | 1 | 7.82 |
| CHEMBL498318 | — | — | 1 | 7.80 |
| CHEMBL524617 | — | — | 1 | 7.66 |
| CHEMBL498319 | — | — | 1 | 7.48 |
| CHEMBL527030 | — | — | 1 | 7.28 |
| CHEMBL497287 | — | — | 1 | 7.12 |
| CHEMBL451660 | — | — | 1 | 7.03 |
| CHEMBL510224 | — | — | 1 | 6.56 |
| CHEMBL526829 | — | — | 1 | 6.45 |
| CHEMBL526828 | — | — | 1 | 6.29 |
| CHEMBL498480 | — | — | 1 | 6.25 |
| CHEMBL523074 | — | — | 1 | 6.22 |
| CHEMBL496269 | — | — | 1 | 5.94 |
| CHEMBL497286 | — | — | 1 | 5.79 |
| CHEMBL497283 | — | — | 1 | - |
| CHEMBL496270 | — | — | 1 | - |
| CHEMBL497465 | — | — | 1 | - |
| CHEMBL497466 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL498311 | — | Ki | = | 0.2 | nM | 9.70 |
| CHEMBL1628268 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL524616 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL525716 | — | Ki | = | 2.0 | nM | 8.70 |
| CHEMBL9946 | CP-154526 | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL309138 | — | Ki | = | 3.0 | nM | 8.52 |
| CHEMBL497651 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL438888 | — | Ki | = | 6.0 | nM | 8.22 |
| CHEMBL497652 | — | Ki | = | 8.0 | nM | 8.10 |
| CHEMBL498667 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL497653 | — | Ki | = | 9.0 | nM | 8.05 |
| CHEMBL497301 | — | Ki | = | 15.0 | nM | 7.82 |
| CHEMBL498318 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL524617 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL498319 | — | Ki | = | 33.0 | nM | 7.48 |
| CHEMBL527030 | — | Ki | = | 53.0 | nM | 7.28 |
| CHEMBL497287 | — | Ki | = | 76.0 | nM | 7.12 |
| CHEMBL451660 | — | Ki | = | 94.0 | nM | 7.03 |
| CHEMBL510224 | — | Ki | = | 277.0 | nM | 6.56 |
| CHEMBL526829 | — | Ki | = | 354.0 | nM | 6.45 |
| CHEMBL526828 | — | Ki | = | 507.0 | nM | 6.29 |
| CHEMBL498480 | — | Ki | = | 561.0 | nM | 6.25 |
| CHEMBL523074 | — | Ki | = | 604.0 | nM | 6.22 |
| CHEMBL496269 | — | Ki | = | 1150.0 | nM | 5.94 |
| CHEMBL497286 | — | Ki | = | 1610.0 | nM | 5.79 |
| CHEMBL497283 | — | Ki | > | 5000.0 | nM | - |
| CHEMBL496270 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL497465 | — | Ki | > | 10000.0 | nM | - |
| CHEMBL497466 | — | Ki | > | 10000.0 | nM | - |