Compound Detail
CHEMBL498667
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Basic Information
| ChEMBL ID | CHEMBL498667 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JAMYKAOGUWWSHK-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
396.4
MW (Da)
4.98
ALogP
6
HBA
0
HBD
62.7
PSA (Ų)
0.60
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 CHEMBL1800 | Ki | 8.05 | 8.05 | 9.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Corticotropin-releasing factor receptor 1 | Ki | = | 9.0 | nM | 8.05 | Displacement of [125I]sauvagine from human CRF1 receptor expressed in IMR32 cell... | 18672365 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18672365 | 10.1016/j.bmcl.2008.07.063 | Corticotropin-releasing factor receptor 1 | 1 |
Data from ChEMBL 36 via Core Engine