Assay Detail
Binding
CHEMBL999083
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Inhibition of mouse AChE
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 7 | 6.25 | 9.39 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL117651 | — | — | 1 | 9.39 |
| CHEMBL540657 | — | — | 1 | 8.05 |
| CHEMBL524365 | — | — | 1 | 5.89 |
| CHEMBL345124 | PROPIDIUM | — | 1 | 5.65 |
| CHEMBL1190 | DECAMETHONIUM | 4.0 | 1 | 5.46 |
| CHEMBL703 | SUXAMETHONIUM | 4.0 | 1 | 4.68 |
| CHEMBL136916 | — | — | 1 | 4.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL117651 | — | Ki | = | 0.41 | nM | 9.39 |
| CHEMBL540657 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL524365 | — | Ki | = | 1300.0 | nM | 5.89 |
| CHEMBL345124 | PROPIDIUM | Ki | = | 2230.0 | nM | 5.65 |
| CHEMBL1190 | DECAMETHONIUM | Ki | = | 3500.0 | nM | 5.46 |
| CHEMBL703 | SUXAMETHONIUM | Ki | = | 21000.0 | nM | 4.68 |
| CHEMBL136916 | — | Ki | = | 23000.0 | nM | 4.64 |