Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL703

SUXAMETHONIUM
💊 Approved Drug
Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
💊 Approved Drug
C[N+](C)(C)CCOC(=O)CCC(=O)OCC[N+](C)(C)C
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL703
Name SUXAMETHONIUM
Phase Approved
Structure Type MOL
InChI Key AXOIZCJOOAYSMI-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Succinylcholine Succinylcholine cation Succinylcholine ion Suxamethonium Suxamethonium cation Suxamethonium ion
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
20
Publications
6
Known Names
3
Indications

Molecular Properties

290.4
MW (Da)
0.27
ALogP
4
HBA
0
HBD
52.6
PSA (Ų)
0.45
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 1952
Availability Prescription
Chirality Achiral

Routes of Administration

Parenteral

Flags

Black Box Warning Natural Product
USAN Stem -ium; -onium

Extended Properties

Molecular Formula C14H30N2O4+2
MW 290.40
Aromatic Rings 0
Heavy Atoms 20
NP-Likeness 0.34

Indications

Myalgia Stroke Bradycardia

ATC Classification

M03AB01
suxamethonium
Level 1: MUSCULO-SKELETAL SYSTEM
Level 2: MUSCLE RELAXANTS

Activity Summary

EC50 1 meas. best 4.52
Ki 1 meas. best 4.68

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Acetylcholinesterase
CHEMBL3198
 Ki 4.68 4.68 21000.0 1
TE-671
CHEMBL615012
 EC50 4.52 4.52 30000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Acetylcholinesterase Ki = 21000.0 nM 4.68 Inhibition of mouse AChE 18479118
TE-671 EC50 = 30000.0 nM 4.52 Stimulation of ion flux in TE671 cells 9435889

Literature References

PubMed DOI Target Context # Activities
22194678 10.1371/journal.pcbi.1002310 Hepatotoxicity 14
11123992 10.1021/jm0010062 Felis catus 6
11123992 10.1021/jm0010062 Monkey 4
37468498 10.1038/s41467-023-40064-9 Thromboxane A2 receptor 2
37468498 10.1038/s41467-023-40064-9 Prostaglandin G/H synthase 1 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 2
26948801 10.1016/j.drudis.2016.02.015 Homo sapiens 2
37468498 10.1038/s41467-023-40064-9 D(1A) dopamine receptor 1
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent noradrenaline transporter 1
37468498 10.1038/s41467-023-40064-9 Acetylcholinesterase 1
37468498 10.1038/s41467-023-40064-9 Estrogen receptor 1
37468498 10.1038/s41467-023-40064-9 Bile salt export pump 1
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
9435889 10.1021/jm970377o TE-671 1
21624500 10.1016/j.drudis.2011.05.007 Hepatotoxicity 1
20020916 10.1080/15376510701857262 Phospholipidosis 1
18479118 10.1021/jm701253t Acetylcholinesterase 1
11123992 10.1021/jm0010062 Gallus gallus 1

Data from ChEMBL 36 via Core Engine