Assay Detail
Binding
CHEMBL999604
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GST-tagged PDE4A
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
3',5'-cyclic-AMP phosphodiesterase 4A (CHEMBL254) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Recent advances on phosphodiesterase 4 inhibitors for the treatment of asthma and chronic obstructive pulmonary disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 8.79 | 9.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL452578 | — | — | 1 | 9.10 |
| CHEMBL323312 | — | — | 1 | 8.89 |
| CHEMBL32442 | CDP840 | — | 1 | 8.38 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL452578 | — | IC50 | = | 0.8 | nM | 9.10 |
| CHEMBL323312 | — | IC50 | = | 1.3 | nM | 8.89 |
| CHEMBL32442 | CDP840 | IC50 | = | 4.2 | nM | 8.38 |