Compound Detail
CHEMBL100661
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CC(C)(C)OC(=O)NCCCN(Cc1cncn1Cc1ccc(C#N)cc1)[C@H]1CCN(Cc2cccc(Cl)c2)C1=O
Basic Information
| ChEMBL ID | CHEMBL100661 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GDPDFNXDSFOTHH-NDEPHWFRSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
577.1
MW (Da)
4.97
ALogP
7
HBA
1
HBD
103.5
PSA (Ų)
0.32
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 8.96 | 8.925 | 1.1 | 2 |
| Geranylgeranyl transferase type-1 subunit beta CHEMBL4135 | IC50 | 5.57 | 5.57 | 2700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 1.1 | nM | 8.96 | Concentration required to displace 50% of a potent radiolabeled FTI from farnesy... | 11520202 |
| Protein farnesyltransferase | IC50 | = | 1.3 | nM | 8.89 | In vitro inhibition of farnesyl transferase using purified recombinant human enz... | 11520202 |
| Geranylgeranyl transferase type-1 subunit beta | IC50 | = | 2700.0 | nM | 5.57 | Inhibitory concentration of geranylgeranyl-protein transferase type I | 11520202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11520202 | 10.1021/jm010156p | Protein farnesyltransferase | 2 |
| 11520202 | 10.1021/jm010156p | Geranylgeranyl transferase type-1 subunit beta | 1 |
| 11520202 | 10.1021/jm010156p | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine