Assay Detail
Binding
CHEMBL683552
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Inhibitory concentration of geranylgeranyl-protein transferase type I
48
Total Activities
48
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
Geranylgeranyl transferase type-1 subunit beta (CHEMBL4135) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Design and biological activity of (S)-4-(5-([1-(3-chlorobenzyl)-2-oxopyrrolidin-3-ylamino]methyl)imidazol-1-ylmethyl)benzonitrile, a 3-aminopyrrolidinone farnesyltransferase inhibitor with excellent cell potency.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 48 | 4.90 | 6.06 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL327278 | — | — | 1 | 6.06 |
| CHEMBL317747 | — | — | 1 | 5.82 |
| CHEMBL100661 | — | — | 1 | 5.57 |
| CHEMBL102107 | — | — | 1 | 5.55 |
| CHEMBL312137 | — | — | 1 | 5.47 |
| CHEMBL98553 | — | — | 1 | 5.44 |
| CHEMBL98711 | — | — | 1 | 5.34 |
| CHEMBL316726 | — | — | 1 | 5.19 |
| CHEMBL99205 | — | — | 1 | 5.19 |
| CHEMBL98314 | — | — | 1 | 5.13 |
| CHEMBL317520 | — | — | 1 | 4.96 |
| CHEMBL318438 | — | — | 1 | 4.96 |
| CHEMBL101561 | — | — | 1 | 4.96 |
| CHEMBL97973 | — | — | 1 | 4.96 |
| CHEMBL100798 | — | — | 1 | 4.92 |
| CHEMBL329067 | — | — | 1 | 4.92 |
| CHEMBL418982 | — | — | 1 | 4.85 |
| CHEMBL327500 | — | — | 1 | 4.82 |
| CHEMBL318943 | — | — | 1 | 4.82 |
| CHEMBL101978 | — | — | 1 | 4.80 |
| CHEMBL101467 | — | — | 1 | 4.72 |
| CHEMBL101564 | — | — | 1 | 4.72 |
| CHEMBL101708 | — | — | 1 | 4.70 |
| CHEMBL327506 | — | — | 1 | 4.62 |
| CHEMBL319737 | — | — | 1 | 4.55 |
| CHEMBL100640 | — | — | 1 | 4.51 |
| CHEMBL102031 | — | — | 1 | 4.44 |
| CHEMBL316502 | — | — | 1 | 4.40 |
| CHEMBL98974 | — | — | 1 | 4.39 |
| CHEMBL100230 | — | — | 1 | 4.39 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL327278 | — | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL317747 | — | IC50 | = | 1500.0 | nM | 5.82 |
| CHEMBL100661 | — | IC50 | = | 2700.0 | nM | 5.57 |
| CHEMBL102107 | — | IC50 | = | 2800.0 | nM | 5.55 |
| CHEMBL312137 | — | IC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL98553 | — | IC50 | = | 3600.0 | nM | 5.44 |
| CHEMBL98711 | — | IC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL316726 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL99205 | — | IC50 | = | 6500.0 | nM | 5.19 |
| CHEMBL98314 | — | IC50 | = | 7400.0 | nM | 5.13 |
| CHEMBL97973 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL101561 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL318438 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL317520 | — | IC50 | = | 11000.0 | nM | 4.96 |
| CHEMBL329067 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL100798 | — | IC50 | = | 12000.0 | nM | 4.92 |
| CHEMBL418982 | — | IC50 | = | 14000.0 | nM | 4.85 |
| CHEMBL327500 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL318943 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL101978 | — | IC50 | = | 16000.0 | nM | 4.80 |
| CHEMBL101467 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL101564 | — | IC50 | = | 19000.0 | nM | 4.72 |
| CHEMBL101708 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL327506 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL319737 | — | IC50 | = | 28000.0 | nM | 4.55 |
| CHEMBL100640 | — | IC50 | = | 31000.0 | nM | 4.51 |
| CHEMBL102031 | — | IC50 | = | 36000.0 | nM | 4.44 |
| CHEMBL316502 | — | IC50 | = | 40000.0 | nM | 4.40 |
| CHEMBL98974 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL100230 | — | IC50 | = | 41000.0 | nM | 4.39 |
| CHEMBL99381 | — | IC50 | = | 42000.0 | nM | 4.38 |
| CHEMBL100579 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL97925 | — | IC50 | = | 46000.0 | nM | 4.34 |
| CHEMBL420833 | — | IC50 | = | 48000.0 | nM | 4.32 |
| CHEMBL317129 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL99435 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL98147 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL101788 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL327946 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL99323 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL98361 | — | IC50 | ~ | 5100.0 | nM | - |
| CHEMBL101509 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL100566 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL101106 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL99371 | — | IC50 | > | 20000.0 | nM | - |
| CHEMBL322007 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL430478 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL99650 | — | IC50 | > | 50000.0 | nM | - |