Compound Detail
CHEMBL98711
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N#Cc1ccc(Cn2cncc2CN(CCCCc2ccccc2)[C@H]2CCN(Cc3ccccc3)C2=O)cc1
Basic Information
| ChEMBL ID | CHEMBL98711 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MLVPMWIOABZTQP-YTTGMZPUSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
517.7
MW (Da)
5.43
ALogP
5
HBA
0
HBD
65.2
PSA (Ų)
0.24
QED
2
Ro5 Violations
12
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein farnesyltransferase CHEMBL2094108 | IC50 | 7.38 | 6.945 | 42.0 | 2 |
| Geranylgeranyl transferase type-1 subunit beta CHEMBL4135 | IC50 | 5.34 | 5.34 | 4600.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein farnesyltransferase | IC50 | = | 42.0 | nM | 7.38 | In vitro inhibition of farnesyl transferase using purified recombinant human enz... | 11520202 |
| Protein farnesyltransferase | IC50 | = | 310.0 | nM | 6.51 | Concentration required to displace 50% of a potent radiolabeled FTI from farnesy... | 11520202 |
| Geranylgeranyl transferase type-1 subunit beta | IC50 | = | 4600.0 | nM | 5.34 | Inhibitory concentration of geranylgeranyl-protein transferase type I | 11520202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11520202 | 10.1021/jm010156p | Protein farnesyltransferase | 2 |
| 11520202 | 10.1021/jm010156p | Geranylgeranyl transferase type-1 subunit beta | 1 |
Data from ChEMBL 36 via Core Engine