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Compound Detail

CHEMBL1078261

PROPIVERINE
🧪 Phase III
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🧪 Phase III
CCCOC(C(=O)OC1CCN(C)CC1)(c1ccccc1)c1ccccc1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL1078261
Name PROPIVERINE
Phase Phase III
Structure Type MOL
InChI Key QPCVHQBVMYCJOM-UHFFFAOYSA-N
Therapeutic ✓ Yes

Known Names

Detrunorm Detrunorm xl Mictonetten Mictonorm NSC-172140 Propiverina Propiverine Propiverine hydrochloride
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
20
Publications
8
Known Names
3
Indications

Molecular Properties

367.5
MW (Da)
3.99
ALogP
4
HBA
0
HBD
38.8
PSA (Ų)
0.69
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Chirality Achiral

Flags

Natural Product
USAN Stem -verine

Extended Properties

Molecular Formula C23H29NO3
MW 367.49
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -0.20

Indications

Polyuria Urinary Incontinence Urinary Bladder, Overactive

ATC Classification

G04BD06
propiverine
Level 1: GENITO URINARY SYSTEM AND SEX HORMONES
Level 2: UROLOGICALS

Activity Summary

IC50 2 meas. best 4.46

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Voltage-dependent L-type calcium channel subunit alpha-1C
CHEMBL2366456
 IC50 4.46 4.46 34700.0 1
Voltage-dependent L-type calcium channel subunit alpha-1C
CHEMBL1940
 IC50 4.38 4.38 41700.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Voltage-dependent L-type calcium channel subunit alpha-1C IC50 = 34700.0 nM 4.46 Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in gu... -
Voltage-dependent L-type calcium channel subunit alpha-1C IC50 = 41700.0 nM 4.38 Inhibition of Cav1.2 calcium current measured using whole cell patch clamp in hu... -

Literature References

PubMed DOI Target Context # Activities
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M1 3
37468498 10.1038/s41467-023-40064-9 Mu-type opioid receptor 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2B 2
37468498 10.1038/s41467-023-40064-9 Nuclear receptor subfamily 1 group I member 2 2
- 10.6019/CHEMBL4808148 Histone deacetylase 6 2
37468498 10.1038/s41467-023-40064-9 Cannabinoid receptor 1 2
37468498 10.1038/s41467-023-40064-9 Progesterone receptor 2
37468498 10.1038/s41467-023-40064-9 Androgen receptor 2
37468498 10.1038/s41467-023-40064-9 Alpha-1A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Alpha-2A adrenergic receptor 2
37468498 10.1038/s41467-023-40064-9 Muscarinic acetylcholine receptor M2 2
37468498 10.1038/s41467-023-40064-9 Gamma-aminobutyric acid receptor subunit alpha-1 2
37468498 10.1038/s41467-023-40064-9 5-hydroxytryptamine receptor 2A 2
37468498 10.1038/s41467-023-40064-9 Sodium-dependent dopamine transporter 1
37468498 10.1038/s41467-023-40064-9 Kappa-type opioid receptor 1
37468498 10.1038/s41467-023-40064-9 Neuronal acetylcholine receptor subunit alpha-4 1
37468498 10.1038/s41467-023-40064-9 Beta-1 adrenergic receptor 1
37468498 10.1038/s41467-023-40064-9 Glutamate receptor ionotropic, NMDA 1 1
37468498 10.1038/s41467-023-40064-9 Voltage-gated inwardly rectifying potassium channel KCNH2 1
20022146 10.1016/j.ejmech.2009.11.034 Homo sapiens 1

Data from ChEMBL 36 via Core Engine