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Compound Detail

CHEMBL1083368

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O=C1c2cccc3cccc(c23)C(=O)N1CC1CCN(CC(O)COc2cccc3[nH]ccc23)CC1

Basic Information

ChEMBL ID CHEMBL1083368
Phase Preclinical
Structure Type MOL
InChI Key NQDCUSHIGOVWHZ-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

483.6
MW (Da)
4.07
ALogP
5
HBA
2
HBD
85.9
PSA (Ų)
0.39
QED
0
Ro5 Violations
7
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H29N3O4
MW 483.57
Aromatic Rings 4
Heavy Atoms 36
NP-Likeness -0.74

Activity Summary

Ki 3 meas. best 7.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-1 adrenergic receptor
CHEMBL213
Ki 7.57 7.57 27.0 1
Beta-2 adrenergic receptor
CHEMBL210
Ki 6.92 6.92 120.0 1
Beta-3 adrenergic receptor
CHEMBL246
Ki 6.0 6.0 1000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20434333 10.1016/j.bmcl.2010.04.009 Beta-1 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-2 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine