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Compound Detail

CHEMBL1083669

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C=CCc1ccccc1OCC(O)CNC1CCN(C)CC1

Basic Information

ChEMBL ID CHEMBL1083669
Phase Preclinical
Structure Type MOL
InChI Key DBKJAXLCJUCMFZ-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

304.4
MW (Da)
1.84
ALogP
4
HBA
2
HBD
44.7
PSA (Ų)
0.72
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H28N2O2
MW 304.43
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.45

Activity Summary

Ki 3 meas. best 8.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 8.62 8.62 2.4 1
Beta-1 adrenergic receptor
CHEMBL213
Ki 6.58 6.58 260.0 1
Beta-3 adrenergic receptor
CHEMBL246
Ki 5.21 5.21 6225.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20434333 10.1016/j.bmcl.2010.04.009 Beta-1 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-2 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-3 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Unchecked 1

Data from ChEMBL 36 via Core Engine