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Compound Detail

CHEMBL1085009

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C=CCc1ccccc1OCC(O)CN1CCC(CN2C(=O)CCCC2=O)CC1

Basic Information

ChEMBL ID CHEMBL1085009
Phase Preclinical
Structure Type MOL
InChI Key YLVVPHSFBDIKPJ-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

400.5
MW (Da)
2.41
ALogP
5
HBA
1
HBD
70.1
PSA (Ų)
0.51
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H32N2O4
MW 400.52
Aromatic Rings 1
Heavy Atoms 29
NP-Likeness -0.73

Activity Summary

Ki 3 meas. best 7.1

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 7.1 7.1 80.0 1
Beta-1 adrenergic receptor
CHEMBL213
Ki 6.36 6.36 440.0 1
Beta-3 adrenergic receptor
CHEMBL246
Ki 4.96 4.96 11000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20434333 10.1016/j.bmcl.2010.04.009 Beta-1 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-2 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine