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Compound Detail

CHEMBL1085014

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C=CCc1ccccc1OCC(O)CN1CCC(CN2C(=O)c3cccc4cc(O)cc(c34)C2=O)CC1

Basic Information

ChEMBL ID CHEMBL1085014
Phase Preclinical
Structure Type MOL
InChI Key WCGAHWOFNPWVLF-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

500.6
MW (Da)
4.02
ALogP
6
HBA
2
HBD
90.3
PSA (Ų)
0.34
QED
1
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C30H32N2O5
MW 500.60
Aromatic Rings 3
Heavy Atoms 37
NP-Likeness -0.40

Activity Summary

Ki 3 meas. best 6.87

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 6.87 6.87 135.0 1
Beta-1 adrenergic receptor
CHEMBL213
Ki 6.77 6.77 170.0 1
Beta-3 adrenergic receptor
CHEMBL246
Ki 5.66 5.66 2200.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20434333 10.1016/j.bmcl.2010.04.009 Beta-1 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-2 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine