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Compound Detail

CHEMBL1085270

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CC(C)c1ccccc1OCC(O)CN1CCC(CN2C(=O)c3ccccc3C2=O)CC1

Basic Information

ChEMBL ID CHEMBL1085270
Phase Preclinical
Structure Type MOL
InChI Key HTODTPFUFZLFBO-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

436.6
MW (Da)
3.56
ALogP
5
HBA
1
HBD
70.1
PSA (Ų)
0.64
QED
0
Ro5 Violations
8
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C26H32N2O4
MW 436.55
Aromatic Rings 2
Heavy Atoms 32
NP-Likeness -0.92

Activity Summary

Ki 3 meas. best 7.77

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-2 adrenergic receptor
CHEMBL210
Ki 7.77 7.77 17.0 1
Beta-1 adrenergic receptor
CHEMBL213
Ki 6.14 6.14 720.0 1
Beta-3 adrenergic receptor
CHEMBL246
Ki 5.83 5.83 1480.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20434333 10.1016/j.bmcl.2010.04.009 Beta-1 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-2 adrenergic receptor 1
20434333 10.1016/j.bmcl.2010.04.009 Beta-3 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine