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Compound Detail

CHEMBL1089387

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O=C(Cn1nc2ccccc2n1)Nc1ccc(CCNC[C@H](O)c2cccnc2)cc1

Basic Information

ChEMBL ID CHEMBL1089387
Phase Preclinical
Structure Type MOL
InChI Key YFPNDOUEDIRYBY-QFIPXVFZSA-N
3
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

416.5
MW (Da)
2.33
ALogP
7
HBA
3
HBD
105.0
PSA (Ų)
0.36
QED
0
Ro5 Violations
9
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C23H24N6O2
MW 416.49
Aromatic Rings 4
Heavy Atoms 31
NP-Likeness -1.38

Activity Summary

IC50 2 meas. best 5.12
EC50 1 meas. best 7.62

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 7.62 7.62 24.0 1
Beta-1 adrenergic receptor
CHEMBL213
IC50 5.12 5.12 7600.0 1
Beta-2 adrenergic receptor
CHEMBL210
IC50 4.89 4.89 13000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20181479 10.1016/j.bmcl.2010.01.130 Beta-3 adrenergic receptor 2
20181479 10.1016/j.bmcl.2010.01.130 Beta-2 adrenergic receptor 1
20181479 10.1016/j.bmcl.2010.01.130 Beta-1 adrenergic receptor 1

Data from ChEMBL 36 via Core Engine