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Compound Detail

CHEMBL110100

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NCCC(CN)NCc1ccc(CNC(CN)CCN)cc1

Basic Information

ChEMBL ID CHEMBL110100
Phase Preclinical
Structure Type MOL
InChI Key BFAMLUAYNATHFN-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

308.5
MW (Da)
-0.78
ALogP
6
HBA
6
HBD
128.1
PSA (Ų)
0.30
QED
1
Ro5 Violations
12
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H32N6
MW 308.47
Aromatic Rings 1
Heavy Atoms 22
NP-Likeness -0.06

Activity Summary

Ki 1 meas. best 5.03

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
T47D
CHEMBL614361
Ki 5.03 5.03 9300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
T47D Ki = 9300.0 nM 5.03 Inhibition of spermidine transport determined in T-47D human breast cancer cells 12951106

Literature References

PubMed DOI Target Context # Activities
12951106 10.1016/s0960-894x(03)00668-1 T47D 1

Data from ChEMBL 36 via Core Engine