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Assay Detail

CHEMBL814811

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Functional
Inhibition of spermidine transport determined in T-47D human breast cancer cells
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type T47D
Confidence 1 — Organism
Curated By Intermediate

Target

T47D (CHEMBL614361)
Type CELL-LINE
Organism Homo sapiens

Publication

Xylylated dimers of putrescine and polyamines: influence of the polyamine backbone on spermidine transport inhibition.
Covassin L, Desjardins M, Soulet D, Charest-Gaudreault R, Audette M, Poulin R.
Bioorg Med Chem Lett (2003) 13 : 3267 -3271
PubMed 12951106 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 13 5.42 5.96

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL419028 1 5.96
CHEMBL47324 1 5.82
CHEMBL423846 1 5.70
CHEMBL23194 SPERMINE 0.5 1 5.68
CHEMBL36119 1 5.57
CHEMBL320562 1 5.55
CHEMBL112759 1 5.55
CHEMBL35633 1 5.47
CHEMBL110528 1 5.03
CHEMBL110100 1 5.03
CHEMBL28743 NORSPERMIDINE 1 5.02
CHEMBL318516 1 4.68
CHEMBL46257 PUTRESCINE 3.0 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL419028 Ki = 1100.0 nM 5.96
CHEMBL47324 Ki = 1500.0 nM 5.82
CHEMBL423846 Ki = 2000.0 nM 5.70
CHEMBL23194 SPERMINE Ki = 2100.0 nM 5.68
CHEMBL36119 Ki = 2700.0 nM 5.57
CHEMBL320562 Ki = 2800.0 nM 5.55
CHEMBL112759 Ki = 2800.0 nM 5.55
CHEMBL35633 Ki = 3400.0 nM 5.47
CHEMBL110528 Ki = 9400.0 nM 5.03
CHEMBL110100 Ki = 9300.0 nM 5.03
CHEMBL28743 NORSPERMIDINE Ki = 9500.0 nM 5.02
CHEMBL318516 Ki = 20900.0 nM 4.68
CHEMBL46257 PUTRESCINE Ki > 500000.0 nM -