Compound Detail
CHEMBL111352
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Basic Information
| ChEMBL ID | CHEMBL111352 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XHPINUDVJRMCQH-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
398.5
MW (Da)
5.04
ALogP
5
HBA
0
HBD
46.3
PSA (Ų)
0.62
QED
1
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 8.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A CHEMBL322 | Ki | 8.17 | 8.17 | 6.8 | 2 |
| 5-hydroxytryptamine receptor 2C CHEMBL225 | Ki | 7.16 | 7.16 | 69.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| 5-hydroxytryptamine receptor 2A | Ki | = | 6.761 | nM | 8.17 | Inhibitory constant on 5-hydroxytryptamine 2A receptor of Rat frontal cortex | 11754579 |
| 5-hydroxytryptamine receptor 2A | Ki | = | 6.761 | nM | 8.17 | Kinetic inhibition constant evaluated by measuring serotonergic activity | 10966742 |
| 5-hydroxytryptamine receptor 2C | Ki | = | 69.18 | nM | 7.16 | Inhibitory constant was determined on 5-hydroxytryptamine 2C receptor of Bovine ... | 11754579 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11754579 | 10.1021/jm011014y | 5-hydroxytryptamine receptor 2A | 2 |
| 11754579 | 10.1021/jm011014y | 5-hydroxytryptamine receptor 2B | 1 |
| 11754579 | 10.1021/jm011014y | 5-hydroxytryptamine receptor 2C | 1 |
| 11754579 | 10.1021/jm011014y | Serotonin receptor 2a and 2b (5HT2A and 5HT2B) | 1 |
| 11754579 | 10.1021/jm011014y | Serotonin receptor 2a and 2c (5HT2A and 5HT2C) | 1 |
| 10966742 | 10.1021/jm000941m | 5-hydroxytryptamine receptor 2A | 1 |
Data from ChEMBL 36 via Core Engine