Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL617323

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Kinetic inhibition constant evaluated by measuring serotonergic activity
25
Total Activities
25
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Expert

Target

5-hydroxytryptamine receptor 2A (CHEMBL322)
Type SINGLE PROTEIN
Organism Rattus norvegicus

Publication

GRid-INdependent descriptors (GRIND): a novel class of alignment-independent three-dimensional molecular descriptors.
Pastor M, Cruciani G, McLay I, Pickett S, Clementi S.
J Med Chem (2000) 43 : 3233 -3243
PubMed 10966742 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Ki 25 7.58 8.84

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL109673 1 8.84
CHEMBL308480 1 8.80
CHEMBL111453 1 8.76
CHEMBL87717 1 8.60
CHEMBL110948 1 8.56
CHEMBL320572 1 8.33
CHEMBL111352 1 8.17
CHEMBL111627 1 8.15
CHEMBL87943 1 8.11
CHEMBL321682 1 7.95
CHEMBL87026 1 7.88
CHEMBL310734 1 7.75
CHEMBL109548 1 7.58
CHEMBL92145 1 7.39
CHEMBL321159 1 7.37
CHEMBL111509 1 7.34
CHEMBL111393 1 7.24
CHEMBL96781 1 7.14
CHEMBL325253 1 6.97
CHEMBL95098 1 6.91
CHEMBL110847 1 6.84
CHEMBL111189 1 6.54
CHEMBL310153 1 6.29
CHEMBL444269 1 6.05
CHEMBL109528 1 5.82

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL109673 Ki = 1.445 nM 8.84
CHEMBL308480 Ki = 1.585 nM 8.80
CHEMBL111453 Ki = 1.738 nM 8.76
CHEMBL87717 Ki = 2.512 nM 8.60
CHEMBL110948 Ki = 2.754 nM 8.56
CHEMBL320572 Ki = 4.677 nM 8.33
CHEMBL111352 Ki = 6.761 nM 8.17
CHEMBL111627 Ki = 7.079 nM 8.15
CHEMBL87943 Ki = 7.762 nM 8.11
CHEMBL321682 Ki = 11.22 nM 7.95
CHEMBL87026 Ki = 13.18 nM 7.88
CHEMBL310734 Ki = 17.78 nM 7.75
CHEMBL109548 Ki = 26.3 nM 7.58
CHEMBL92145 Ki = 40.74 nM 7.39
CHEMBL321159 Ki = 42.66 nM 7.37
CHEMBL111509 Ki = 45.71 nM 7.34
CHEMBL111393 Ki = 57.54 nM 7.24
CHEMBL96781 Ki = 72.44 nM 7.14
CHEMBL325253 Ki = 107.15 nM 6.97
CHEMBL95098 Ki = 123.03 nM 6.91
CHEMBL110847 Ki = 144.54 nM 6.84
CHEMBL111189 Ki = 288.4 nM 6.54
CHEMBL310153 Ki = 512.86 nM 6.29
CHEMBL444269 Ki = 891.25 nM 6.05
CHEMBL109528 Ki = 1513.56 nM 5.82