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Compound Detail

CHEMBL111521

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CC(=O)N1CCN(CC#CCN2CCCC2)C1=O

Basic Information

ChEMBL ID CHEMBL111521
Phase Preclinical
Structure Type MOL
InChI Key SNJAYQZCSQSCPO-UHFFFAOYSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

249.3
MW (Da)
0.37
ALogP
3
HBA
0
HBD
43.9
PSA (Ų)
0.66
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H19N3O2
MW 249.31
Aromatic Rings 0
Heavy Atoms 18
NP-Likeness -1.01

Activity Summary

Ki 1 meas. best 4.56

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 4.56 4.56 27400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor M3 3
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine