Assay Detail
Binding
CHEMBL748179
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Displacement of [3H]3-quinuclidinyl benzilate ([3H]-QNB) from muscarinic acetylcholine receptor of rat cerebral cortex
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Rattus norvegicus |
| Tissue | Cerebral cortex |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Urea and 2-imidazolidone derivatives of the muscarinic agents oxotremorine and N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 13 | 5.67 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL51682 | — | — | 1 | 7.23 |
| CHEMBL310852 | — | — | 1 | 7.22 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 6.64 |
| CHEMBL109626 | — | — | 1 | 6.38 |
| CHEMBL109293 | — | — | 1 | 6.19 |
| CHEMBL77079 | — | — | 1 | 5.80 |
| CHEMBL326381 | — | — | 1 | 5.38 |
| CHEMBL76385 | — | — | 1 | 5.19 |
| CHEMBL110018 | — | — | 1 | 4.97 |
| CHEMBL321674 | — | — | 1 | 4.80 |
| CHEMBL111467 | — | — | 1 | 4.76 |
| CHEMBL109467 | — | — | 1 | 4.58 |
| CHEMBL111521 | — | — | 1 | 4.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL51682 | — | Ki | = | 59.0 | nM | 7.23 |
| CHEMBL310852 | — | Ki | = | 60.0 | nM | 7.22 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 230.0 | nM | 6.64 |
| CHEMBL109626 | — | Ki | = | 420.0 | nM | 6.38 |
| CHEMBL109293 | — | Ki | = | 640.0 | nM | 6.19 |
| CHEMBL77079 | — | Ki | = | 1600.0 | nM | 5.80 |
| CHEMBL326381 | — | Ki | = | 4200.0 | nM | 5.38 |
| CHEMBL76385 | — | Ki | = | 6500.0 | nM | 5.19 |
| CHEMBL110018 | — | Ki | = | 10700.0 | nM | 4.97 |
| CHEMBL321674 | — | Ki | = | 15800.0 | nM | 4.80 |
| CHEMBL111467 | — | Ki | = | 17200.0 | nM | 4.76 |
| CHEMBL109467 | — | Ki | = | 26400.0 | nM | 4.58 |
| CHEMBL111521 | — | Ki | = | 27400.0 | nM | 4.56 |