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Compound Detail

CHEMBL77079

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CN1CCN(CC#CCN2CCCC2)C1=O

Basic Information

ChEMBL ID CHEMBL77079
Phase Preclinical
Structure Type MOL
InChI Key WSUDGBJNOLZUBI-UHFFFAOYSA-N
2
Targets
5
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

221.3
MW (Da)
0.45
ALogP
2
HBA
0
HBD
26.8
PSA (Ų)
0.63
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H19N3O
MW 221.30
Aromatic Rings 0
Heavy Atoms 16
NP-Likeness -0.99

Activity Summary

Ki 3 meas. best 8.57
EC50 1 meas. best 7.0
Kd 1 meas. best 5.54

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 8.57 7.04 2.7 3
Muscarinic acetylcholine receptor M3
CHEMBL5498
EC50 7.0 7.0 100.0 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 5.54 5.54 2900.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1875333 10.1021/jm00112a002 Mus musculus 6
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor M3 4
1875333 10.1021/jm00112a002 Muscarinic acetylcholine receptor 3
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine