Assay Detail
Binding
CHEMBL752170
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Binding affinity to muscarinic acetylcholine receptor was determined in presence of [3H]OXO-M radioligand (in vitro)
66
Total Activities
66
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Muscarinic acetylcholine receptor (CHEMBL1907609) ↗| Type | PROTEIN FAMILY |
| Organism | Rattus norvegicus |
Publication
Cholinergic activity of acetylenic imidazoles and related compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 66 | 7.92 | 9.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL77793 | — | — | 1 | 9.52 |
| CHEMBL7634 | OXOTREMORINE | — | 1 | 9.30 |
| CHEMBL310852 | — | — | 1 | 9.07 |
| CHEMBL11081 | — | — | 1 | 9.04 |
| CHEMBL51682 | — | — | 1 | 8.96 |
| CHEMBL41779 | — | — | 1 | 8.96 |
| CHEMBL306366 | — | — | 1 | 8.89 |
| CHEMBL76067 | — | — | 1 | 8.82 |
| CHEMBL51405 | — | — | 1 | 8.82 |
| CHEMBL306376 | — | — | 1 | 8.80 |
| CHEMBL75111 | — | — | 1 | 8.78 |
| CHEMBL77636 | — | — | 1 | 8.72 |
| CHEMBL308605 | — | — | 1 | 8.68 |
| CHEMBL73257 | — | — | 1 | 8.59 |
| CHEMBL77079 | — | — | 1 | 8.57 |
| CHEMBL306825 | — | — | 1 | 8.49 |
| CHEMBL75805 | — | — | 1 | 8.44 |
| CHEMBL74917 | — | — | 1 | 8.44 |
| CHEMBL75358 | — | — | 1 | 8.38 |
| CHEMBL421127 | — | — | 1 | 8.35 |
| CHEMBL307612 | — | — | 1 | 8.28 |
| CHEMBL75295 | — | — | 1 | 8.24 |
| CHEMBL48269 | — | — | 1 | 8.15 |
| CHEMBL307512 | — | — | 1 | 8.15 |
| CHEMBL73848 | — | — | 1 | 8.07 |
| CHEMBL74792 | — | — | 1 | 8.05 |
| CHEMBL307600 | — | — | 1 | 8.02 |
| CHEMBL78262 | — | — | 1 | 8.00 |
| CHEMBL77432 | — | — | 1 | 7.99 |
| CHEMBL73404 | — | — | 1 | 7.99 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL77793 | — | Ki | = | 0.3 | nM | 9.52 |
| CHEMBL7634 | OXOTREMORINE | Ki | = | 0.5 | nM | 9.30 |
| CHEMBL310852 | — | Ki | = | 0.86 | nM | 9.07 |
| CHEMBL11081 | — | Ki | = | 0.92 | nM | 9.04 |
| CHEMBL51682 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL41779 | — | Ki | = | 1.1 | nM | 8.96 |
| CHEMBL306366 | — | Ki | = | 1.3 | nM | 8.89 |
| CHEMBL76067 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL51405 | — | Ki | = | 1.5 | nM | 8.82 |
| CHEMBL306376 | — | Ki | = | 1.6 | nM | 8.80 |
| CHEMBL75111 | — | Ki | = | 1.68 | nM | 8.78 |
| CHEMBL77636 | — | Ki | = | 1.92 | nM | 8.72 |
| CHEMBL308605 | — | Ki | = | 2.1 | nM | 8.68 |
| CHEMBL73257 | — | Ki | = | 2.6 | nM | 8.59 |
| CHEMBL77079 | — | Ki | = | 2.7 | nM | 8.57 |
| CHEMBL306825 | — | Ki | = | 3.2 | nM | 8.49 |
| CHEMBL75805 | — | Ki | = | 3.61 | nM | 8.44 |
| CHEMBL74917 | — | Ki | = | 3.6 | nM | 8.44 |
| CHEMBL75358 | — | Ki | = | 4.2 | nM | 8.38 |
| CHEMBL421127 | — | Ki | = | 4.5 | nM | 8.35 |
| CHEMBL307612 | — | Ki | = | 5.22 | nM | 8.28 |
| CHEMBL75295 | — | Ki | = | 5.7 | nM | 8.24 |
| CHEMBL48269 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL307512 | — | Ki | = | 7.1 | nM | 8.15 |
| CHEMBL73848 | — | Ki | = | 8.6 | nM | 8.07 |
| CHEMBL74792 | — | Ki | = | 8.9 | nM | 8.05 |
| CHEMBL307600 | — | Ki | = | 9.5 | nM | 8.02 |
| CHEMBL78262 | — | Ki | = | 10.0 | nM | 8.00 |
| CHEMBL77432 | — | Ki | = | 10.3 | nM | 7.99 |
| CHEMBL73404 | — | Ki | = | 10.2 | nM | 7.99 |
| CHEMBL77160 | — | Ki | = | 12.0 | nM | 7.92 |
| CHEMBL76385 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL309080 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL74426 | — | Ki | = | 13.0 | nM | 7.89 |
| CHEMBL76059 | — | Ki | = | 14.6 | nM | 7.84 |
| CHEMBL78304 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL73871 | — | Ki | = | 16.0 | nM | 7.80 |
| CHEMBL74424 | — | Ki | = | 18.0 | nM | 7.75 |
| CHEMBL77348 | — | Ki | = | 19.0 | nM | 7.72 |
| CHEMBL75026 | — | Ki | = | 22.0 | nM | 7.66 |
| CHEMBL307051 | — | Ki | = | 23.0 | nM | 7.64 |
| CHEMBL77870 | — | Ki | = | 26.4 | nM | 7.58 |
| CHEMBL75144 | — | Ki | = | 29.1 | nM | 7.54 |
| CHEMBL311856 | — | Ki | = | 33.5 | nM | 7.47 |
| CHEMBL74265 | — | Ki | = | 35.0 | nM | 7.46 |
| CHEMBL309829 | — | Ki | = | 36.0 | nM | 7.44 |
| CHEMBL74264 | — | Ki | = | 37.0 | nM | 7.43 |
| CHEMBL75033 | — | Ki | = | 39.0 | nM | 7.41 |
| CHEMBL77886 | — | Ki | = | 43.0 | nM | 7.37 |
| CHEMBL78046 | — | Ki | = | 53.0 | nM | 7.28 |