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Compound Detail

CHEMBL78046

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Cc1c[n+](C)cn1CC#CCN1CCCC1=O.[I-]

Basic Information

ChEMBL ID CHEMBL78046
Phase Preclinical
Structure Type MOL
InChI Key KWCRTVGXKRCRNF-UHFFFAOYSA-M
Parent Compound CHEMBL1179485
Active Moiety CHEMBL1179485
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

232.3
MW (Da)
0.25
ALogP
2
HBA
0
HBD
29.1
PSA (Ų)
0.53
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C13H18IN3O
MW 359.21
Aromatic Rings 1
Heavy Atoms 17
NP-Likeness -0.47

Activity Summary

Ki 2 meas. best 7.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 7.28 6.9 53.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1875333 10.1021/jm00112a002 Mus musculus 6
1875333 10.1021/jm00112a002 Muscarinic acetylcholine receptor 3

Data from ChEMBL 36 via Core Engine