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Compound Detail

CHEMBL76385

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O=C1NCCN1CC#CCN1CCCC1

Basic Information

ChEMBL ID CHEMBL76385
Phase Preclinical
Structure Type MOL
InChI Key NNQOKFWDPAVGRK-UHFFFAOYSA-N
2
Targets
5
Activities
3
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

207.3
MW (Da)
0.11
ALogP
2
HBA
1
HBD
35.6
PSA (Ų)
0.65
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H17N3O
MW 207.28
Aromatic Rings 0
Heavy Atoms 15
NP-Likeness -1.16

Activity Summary

Ki 3 meas. best 7.89
EC50 1 meas. best 5.57
Kd 1 meas. best 4.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 7.89 6.3933 13.0 3
Muscarinic acetylcholine receptor M3
CHEMBL5498
EC50 5.57 5.57 2670.0 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 4.52 4.52 30300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1875333 10.1021/jm00112a002 Mus musculus 6
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor M3 4
1875333 10.1021/jm00112a002 Muscarinic acetylcholine receptor 3
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine