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Compound Detail

CHEMBL109467

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O=CN1CCN(CC#CCN2CCCC2)C1=O

Basic Information

ChEMBL ID CHEMBL109467
Phase Preclinical
Structure Type MOL
InChI Key SVBMFZQZSJVEJC-UHFFFAOYSA-N
2
Targets
3
Activities
3
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

235.3
MW (Da)
-0.02
ALogP
3
HBA
0
HBD
43.9
PSA (Ų)
0.51
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C12H17N3O2
MW 235.29
Aromatic Rings 0
Heavy Atoms 17
NP-Likeness -0.72

Activity Summary

EC50 1 meas. best 5.07
Kd 1 meas. best 4.68
Ki 1 meas. best 4.58

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL5498
EC50 5.07 5.07 8600.0 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 4.68 4.68 20900.0 1
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 4.58 4.58 26400.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor M3 4
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine