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Compound Detail

CHEMBL111467

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O=C1CNC(=O)N1CC#CCN1CCCC1

Basic Information

ChEMBL ID CHEMBL111467
Phase Preclinical
Structure Type MOL
InChI Key KKKHJOFUUPJCNK-UHFFFAOYSA-N
2
Targets
3
Activities
3
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

221.3
MW (Da)
-0.36
ALogP
3
HBA
1
HBD
52.6
PSA (Ų)
0.51
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H15N3O2
MW 221.26
Aromatic Rings 0
Heavy Atoms 16
NP-Likeness -1.16

Activity Summary

EC50 1 meas. best 4.33
Kd 1 meas. best 4.0
Ki 1 meas. best 4.76

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor
CHEMBL1907609
Ki 4.76 4.76 17200.0 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
EC50 4.33 4.33 46400.0 1
Muscarinic acetylcholine receptor M3
CHEMBL5498
Kd 4.0 4.0 100000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor M3 4
1507212 10.1021/jm00095a025 Muscarinic acetylcholine receptor 1

Data from ChEMBL 36 via Core Engine