Compound Detail
CHEMBL113181
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Basic Information
| ChEMBL ID | CHEMBL113181 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IZKMDIXJFSCFAU-HSBNLIEZSA-N |
| Parent Compound | CHEMBL1180088 |
| Active Moiety | CHEMBL1180088 |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
301.4
MW (Da)
3.79
ALogP
4
HBA
2
HBD
70.5
PSA (Ų)
0.32
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 2 meas. best 8.31
Kd 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL4124 | Ki | 8.31 | 8.305 | 4.9 | 2 |
| Cavia porcellus CHEMBL369 | Kd | 7.7 | 7.7 | 19.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 4.9 | nM | 8.31 | Histamine H3 receptor antagonist activity in an assay with K+ evoked depolarizat... | 10966752 |
| Histamine H3 receptor | Ki | = | 5.012 | nM | 8.3 | Antagonist activity against Histamine H3 receptor in an assay with K+ -evolved d... | 10966752 |
| Cavia porcellus | Kd | = | 19.95 | nM | 7.7 | Inhibition of electrically evoked twitches of isolated guinea pig ileal segments... | 10966752 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10966752 | 10.1021/jm000971p | Histamine H3 receptor | 2 |
| 10966752 | 10.1021/jm000971p | Mus musculus | 1 |
| 10966752 | 10.1021/jm000971p | Cavia porcellus | 1 |
| 10966752 | 10.1021/jm000971p | Histamine H2 receptor | 1 |
| 10966752 | 10.1021/jm000971p | Histamine H1 receptor | 1 |
Data from ChEMBL 36 via Core Engine