Compound Detail
CHEMBL1141
POTASSIUM IODIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1141 |
| Name | POTASSIUM IODIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | NLKNQRATVPKPDG-UHFFFAOYSA-M |
| Therapeutic | ✓ Yes |
1
Targets
6
Activities
1
Assay Types
0
PK Parameters
10
Publications
13
Known Names
8
Indications
1
Mechanisms
Molecular Properties
166.0
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1979 |
| Availability | OTC |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Unknown | - | - | ✓ | ✓ |
Indications
Anemia Eye Diseases Graves Disease Hyperthyroidism Pregnancy Lymphoma Lymphoma, Non-Hodgkin Neuroblastoma
ATC Classification
R05CA02
potassium iodide
Level 1: RESPIRATORY SYSTEM
Level 2: COUGH AND COLD PREPARATIONS
S01XA04
potassium iodide
Level 1: SENSORY ORGANS
Level 2: OPHTHALMOLOGICALS
V03AB21
potassium iodide
Level 1: VARIOUS
Level 2: ALL OTHER THERAPEUTIC PRODUCTS
Drug Warnings
Black Box Warning
vascular toxicity
Activity Summary
Ki 6 meas. best 4.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Carbonic anhydrase 4 CHEMBL3729 | Ki | 4.1 | 4.1 | 80000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 4 | Ki | = | 80000.0 | nM | 4.1 | Inhibition of human carbonic anhydrase 4 by Lineweaver-Burk curves | 21211980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4495565 | SARS-CoV-2 | 2 |
| 9873700 | 10.1016/s0960-894x(98)00585-x | Escherichia coli | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Unchecked | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 1 | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 2 | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 4 | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 5A, mitochondrial | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 9 | 1 |
| - | 10.21203/rs.3.rs-23951/v1 | SARS-CoV-2 | 1 |
| - | 10.6019/CHEMBL4495564 | Replicase polyprotein 1ab | 1 |
Data from ChEMBL 36 via Core Engine