Compound Detail
CHEMBL1160362
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Basic Information
| ChEMBL ID | CHEMBL1160362 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QCSGZYRCELECJV-UHFFFAOYSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
434.1
MW (Da)
-3.24
ALogP
9
HBA
9
HBD
261.0
PSA (Ų)
0.18
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 6.36
IC50 1 meas. best 7.57
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Inositol 1,4,5-trisphosphate binding protein CHEMBL3364 | IC50 | 7.57 | 7.57 | 27.0 | 1 |
| Oryctolagus cuniculus CHEMBL374 | EC50 | 6.36 | 6.36 | 440.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Inositol 1,4,5-trisphosphate binding protein | IC50 | = | 27.0 | nM | 7.57 | Compound was tested for inhibition of specific [3H]Ins(1,4,5)P3 binding to Inosi... | - |
| Oryctolagus cuniculus | EC50 | = | 440.0 | nM | 6.36 | Compound was tested for its ability to release [Ca2+] from permeabilised rabbit ... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(96)00399-X | Inositol 1,4,5-trisphosphate binding protein | 1 |
| - | 10.1016/0960-894X(96)00399-X | Oryctolagus cuniculus | 1 |
Data from ChEMBL 36 via Core Engine