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Compound Detail

CHEMBL1161978

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CC1CC(C)(C)Nc2c1cc1c(c2S(=O)(=O)O)OC2C(=C1c1c(Cl)c(SCC(=O)NCCCCCC(=O)N(C(=O)[C@H]3CCN(C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc4ccccc4)NC(=O)[C@@H](Cc4ccc(O)cc4)N(C)C(=O)CCc4ccc(O)cc4)C3)[C@@H](CCCCN)C(N)=O)c(Cl)c(Cl)c1C(=O)O)CC1C(=NC(C)(C)CC1C)C2S(=O)(=O)O

Basic Information

ChEMBL ID CHEMBL1161978
Phase Preclinical
Structure Type MOL
InChI Key SVLGRIWNJNOFJU-CRAMPYNJSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

2060.7
MW (Da)

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C94H122Cl3N17O23S3
MW 2060.67

Activity Summary

Ki 3 meas. best 10.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Vasopressin V1a receptor
CHEMBL1889
Ki 10.05 10.05 0.1 1
Oxytocin receptor
CHEMBL2049
Ki 8.98 8.98 1.0 1
Vasopressin V1b receptor
CHEMBL1921
Ki 7.0 7.0 100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
17850055 10.1021/jm061404q Vasopressin V1a receptor 3
17850055 10.1021/jm061404q Oxytocin receptor 3
17850055 10.1021/jm061404q Vasopressin V1b receptor 1
17850055 10.1021/jm061404q Vasopressin V2 receptor 1

Data from ChEMBL 36 via Core Engine