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Compound Detail

CHEMBL1164820

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COc1cc(C(=O)O[C@H]2CCCC[C@@H]2OC(=O)c2ccc(O)c(OC)c2)ccc1O

Basic Information

ChEMBL ID CHEMBL1164820
Phase Preclinical
Structure Type MOL
InChI Key CJJVDYUOTKHCBA-ROUUACIJSA-N
7
Targets
8
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

416.4
MW (Da)
3.44
ALogP
8
HBA
2
HBD
111.5
PSA (Ų)
0.69
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H24O8
MW 416.43
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness 0.38

Activity Summary

IC50 8 meas. best 4.35

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.35 4.315 45000.0 2
B16-F10
CHEMBL612656
IC50 4.23 4.23 59000.0 1
LoVo
CHEMBL614721
IC50 4.19 4.19 64000.0 1
MCF7
CHEMBL387
IC50 4.12 4.12 75000.0 1
A549
CHEMBL392
IC50 4.12 4.12 76000.0 1
OE33
CHEMBL1075556
IC50 4.11 4.11 77000.0 1
PC-3
CHEMBL390
IC50 4.11 4.11 77000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine