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Compound Detail

CHEMBL1165153

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COc1ccc(-c2nnn(CCCCCCCn3nnnc3-c3ccc(OC)c(OC)c3)n2)cc1OC

Basic Information

ChEMBL ID CHEMBL1165153
Phase Preclinical
Structure Type MOL
InChI Key LYQFYRDFHDRAHI-UHFFFAOYSA-N
5
Targets
7
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

508.6
MW (Da)
3.68
ALogP
12
HBA
0
HBD
124.1
PSA (Ų)
0.23
QED
2
Ro5 Violations
14
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H32N8O4
MW 508.58
Aromatic Rings 4
Heavy Atoms 37
NP-Likeness -1.40

Activity Summary

IC50 7 meas. best 4.39

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
LoVo
CHEMBL614721
IC50 4.39 4.39 41000.0 1
A549
CHEMBL392
IC50 4.28 4.28 52000.0 1
T98G
CHEMBL614775
IC50 4.26 4.26 55000.0 1
MCF7
CHEMBL387
IC50 4.15 4.15 71000.0 1
NON-PROTEIN TARGET
CHEMBL3879801
IC50 4.1 4.0767 80000.0 3

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine