Compound Detail
CHEMBL1173391
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Basic Information
| ChEMBL ID | CHEMBL1173391 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YQSXEBUURNJWNA-UHFFFAOYSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
4.54
ALogP
2
HBA
1
HBD
31.9
PSA (Ų)
0.77
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.46
Ki 1 meas. best 7.21
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Ki | 7.21 | 7.21 | 61.0 | 1 |
| Histamine H3 receptor CHEMBL264 | IC50 | 6.46 | 6.46 | 347.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 61.0 | nM | 7.21 | Displacement of [3H] (R)-alpha-methylhistamine from human recombinant histamine ... | 20541426 |
| Histamine H3 receptor | IC50 | = | 347.0 | nM | 6.46 | Antagonist activity at human recombinant histamine H3 receptor expressed in CHO-... | 20541426 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20541426 | 10.1016/j.bmc.2010.04.052 | Histamine H3 receptor | 4 |
Data from ChEMBL 36 via Core Engine