Compound Detail
CHEMBL119420
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL119420 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YZDRSBRUONQQBH-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
398.6
MW (Da)
6.39
ALogP
0
HBA
0
HBD
7.8
PSA (Ų)
0.20
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Small conductance calcium-activated potassium channel CHEMBL2096673 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
| Rattus norvegicus CHEMBL376 | IC50 | 4.68 | 4.68 | 21000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Rattus norvegicus | IC50 | = | 21000.0 | nM | 4.68 | Ability to inhibit the hyperpolarization (AHP) in cultured rat sympathetic neuro... | - |
| Small conductance calcium-activated potassium channel | IC50 | = | 21000.0 | nM | 4.68 | The SKCa-blocking action was assessed by its ability to inhibit the after hyperp... | 7658440 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.1016/0960-894X(95)00073-3 | Rattus norvegicus | 3 |
| 7658440 | 10.1021/jm00018a013 | Small conductance calcium-activated potassium channel | 1 |
| 7658440 | 10.1021/jm00018a013 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine