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Compound Detail

CHEMBL119615

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C[C@@H]1CCN(CC#CCN(C)C)C1=O

Basic Information

ChEMBL ID CHEMBL119615
Phase Preclinical
Structure Type MOL
InChI Key ZLYDESMUNQSKFD-SNVBAGLBSA-N
2
Targets
5
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

194.3
MW (Da)
0.42
ALogP
2
HBA
0
HBD
23.6
PSA (Ų)
0.59
QED
0
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C11H18N2O
MW 194.28
Aromatic Rings 0
Heavy Atoms 14
NP-Likeness -0.51

Activity Summary

Ki 5 meas. best 7.15

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M2
CHEMBL309
Ki 7.15 5.9625 71.0 4
Muscarinic acetylcholine receptor M1
CHEMBL276
Ki 5.17 5.17 6800.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
8246221 10.1021/jm00075a007 Muscarinic acetylcholine receptor M2 5
8246221 10.1021/jm00075a007 Muscarinic receptor M1 and M2 3
8246221 10.1021/jm00075a007 Muscarinic acetylcholine receptor M1 1

Data from ChEMBL 36 via Core Engine