Compound Detail
CHEMBL1200731
POTASSIUM CHLORIDE 💊 Approved Drug
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💊 Approved Drug
Basic Information
| ChEMBL ID | CHEMBL1200731 |
| Name | POTASSIUM CHLORIDE |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | WCUXLLCKKVVCTQ-UHFFFAOYSA-M |
1
Targets
13
Activities
2
Assay Types
0
PK Parameters
11
Publications
30
Known Names
17
Indications
1
Mechanisms
Molecular Properties
74.5
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| First Approval | 1982 |
| Availability | Prescription |
| Chirality | Achiral |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Supplement | - | - | ✓ | ✓ |
Indications
Acid-Base Imbalance Arrhythmias, Cardiac Fluid Therapy Hemorrhage Angina, Unstable Constipation Coronary Disease Heart Diseases Heart Failure Heart Failure Hypertension Myocardial Infarction Aortic Valve Stenosis Brain Neoplasms Heart Arrest Heart Failure, Diastolic Shock, Septic
ATC Classification
A12BA01
potassium chloride
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: MINERAL SUPPLEMENTS
A12BA51
potassium, combinations
Level 1: ALIMENTARY TRACT AND METABOLISM
Level 2: MINERAL SUPPLEMENTS
B05XA01
potassium chloride
Level 1: BLOOD AND BLOOD FORMING ORGANS
Level 2: BLOOD SUBSTITUTES AND PERFUSION SOLUTIONS
Activity Summary
EC50 8 meas.
Ki 5 meas. best 4.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Carbonic anhydrase 4 CHEMBL3729 | Ki | 4.05 | 4.05 | 90000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 4 | Ki | = | 90000.0 | nM | 4.05 | Inhibition of human carbonic anhydrase 4 by Lineweaver-Burk curves | 21211980 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 22194678 | 10.1371/journal.pcbi.1002310 | Hepatotoxicity | 14 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Unchecked | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 1 | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 2 | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 4 | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 5A, mitochondrial | 1 |
| 21211980 | 10.1016/j.bmc.2010.12.033 | Carbonic anhydrase 9 | 1 |
| 27560386 | 10.1021/acs.jnatprod.6b00494 | Unchecked | 1 |
| 27491708 | 10.1016/j.bmcl.2016.07.054 | Unchecked | 1 |
| - | 10.5281/zenodo.7360329 | Sodium/potassium/calcium exchanger 2 | 1 |
| - | 10.5281/zenodo.7360317 | Sodium/potassium/calcium exchanger 4 | 1 |
Data from ChEMBL 36 via Core Engine