Compound Detail
CHEMBL1215001
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Basic Information
| ChEMBL ID | CHEMBL1215001 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | YKWMQNUCOUUHQO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
382.5
MW (Da)
1.24
ALogP
7
HBA
3
HBD
105.4
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase D1 CHEMBL3863 | IC50 | 9.0 | 9.0 | 1.0 | 1 |
| Serine/threonine-protein kinase D2 CHEMBL4900 | IC50 | 8.05 | 8.05 | 9.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase D1 | IC50 | = | 1.0 | nM | 9.0 | Inhibition of PKD1 by TR-FRET assay | 20684592 |
| Serine/threonine-protein kinase D2 | IC50 | = | 9.0 | nM | 8.05 | Inhibition of PKD2 by TR-FRET assay | 20684592 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 20684592 | 10.1021/jm100076w | Serine/threonine-protein kinase D1 | 2 |
| 20684592 | 10.1021/jm100076w | Serine/threonine-protein kinase D2 | 1 |
Data from ChEMBL 36 via Core Engine