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Compound Detail

CHEMBL1215077

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CCNc1cc(-c2cc(C(N)=O)cc(N3CCNCC3)n2)ccn1

Basic Information

ChEMBL ID CHEMBL1215077
Phase Preclinical
Structure Type MOL
InChI Key VBWZGQKYVCFADL-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

326.4
MW (Da)
1.08
ALogP
6
HBA
3
HBD
96.2
PSA (Ų)
0.76
QED
0
Ro5 Violations
5
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C17H22N6O
MW 326.40
Aromatic Rings 2
Heavy Atoms 24
NP-Likeness -1.30

Activity Summary

IC50 2 meas. best 8.4

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Serine/threonine-protein kinase D1
CHEMBL3863
IC50 8.4 8.4 4.0 1
Serine/threonine-protein kinase D2
CHEMBL4900
IC50 7.51 7.51 31.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
20684592 10.1021/jm100076w Serine/threonine-protein kinase D1 2
20684592 10.1021/jm100076w Serine/threonine-protein kinase D2 1

Data from ChEMBL 36 via Core Engine