Compound Detail
CHEMBL1241462
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Basic Information
| ChEMBL ID | CHEMBL1241462 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VXNHTGWDWVCFSI-UHFFFAOYSA-N |
2
Targets
3
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
228.3
MW (Da)
1.94
ALogP
3
HBA
2
HBD
53.6
PSA (Ų)
0.83
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 6.24
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 CHEMBL4204 | IC50 | 6.24 | 6.24 | 575.0 | 1 |
| MAP kinase-interacting serine/threonine-protein kinase 1 CHEMBL4718 | IC50 | 6.19 | 5.725 | 646.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MAP kinase-interacting serine/threonine-protein kinase 2 | IC50 | = | 575.0 | nM | 6.24 | Inhibition of MNK2 | 20722422 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | IC50 | = | 646.0 | nM | 6.19 | Inhibition of MNK1 | 20722422 |
| MAP kinase-interacting serine/threonine-protein kinase 1 | IC50 | = | 5500.0 | nM | 5.26 | Inhibition of full length GST-tagged recombinant human MNK1 expressed in insect ... | 29526098 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38315032 | 10.1021/acs.jmedchem.3c02441 | RAW264.7 | 2 |
| 20722422 | 10.1021/jm1005513 | MAP kinase-interacting serine/threonine-protein kinase 1 | 2 |
| 20722422 | 10.1021/jm1005513 | Fibroblast growth factor receptor 1 | 1 |
| 20722422 | 10.1021/jm1005513 | Mitogen-activated protein kinase 14 | 1 |
| 20722422 | 10.1021/jm1005513 | Serine/threonine-protein kinase 4 | 1 |
| 20722422 | 10.1021/jm1005513 | Hepatocyte growth factor receptor | 1 |
| 20722422 | 10.1021/jm1005513 | Dual specificity mitogen-activated protein kinase kinase 1 | 1 |
| 20722422 | 10.1021/jm1005513 | Mast/stem cell growth factor receptor Kit | 1 |
| 20722422 | 10.1021/jm1005513 | Tyrosine-protein kinase JAK2 | 1 |
| 20722422 | 10.1021/jm1005513 | Inhibitor of nuclear factor kappa-B kinase subunit beta | 1 |
| 20722422 | 10.1021/jm1005513 | Insulin-like growth factor 1 receptor | 1 |
| 20722422 | 10.1021/jm1005513 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 20722422 | 10.1021/jm1005513 | Focal adhesion kinase 1 | 1 |
| 20722422 | 10.1021/jm1005513 | Mitogen-activated protein kinase 3 | 1 |
| 20722422 | 10.1021/jm1005513 | Epidermal growth factor receptor | 1 |
| 20722422 | 10.1021/jm1005513 | Dual specificity tyrosine-phosphorylation-regulated kinase 1A | 1 |
| 20722422 | 10.1021/jm1005513 | Casein kinase I isoform alpha | 1 |
| 20722422 | 10.1021/jm1005513 | Serine/threonine-protein kinase B-raf | 1 |
| 20722422 | 10.1021/jm1005513 | NUAK family SNF1-like kinase 1 | 1 |
| 20722422 | 10.1021/jm1005513 | RAC-alpha serine/threonine-protein kinase | 1 |
Data from ChEMBL 36 via Core Engine