Compound Detail
CHEMBL124317
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Basic Information
| ChEMBL ID | CHEMBL124317 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GFGVSPYXQBYZOT-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
459.6
MW (Da)
6.13
ALogP
3
HBA
2
HBD
61.4
PSA (Ų)
0.42
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.9
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| C-C chemokine receptor type 3 CHEMBL3473 | IC50 | 6.9 | 6.9 | 125.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| C-C chemokine receptor type 3 | IC50 | = | 125.0 | nM | 6.9 | Inhibitory activity against recombinant human Chemokine receptor type 3 (CCR3) e... | 12166951 |
| C-C chemokine receptor type 3 | IC50 | = | 125.0 | nM | 6.9 | Inhibition of [125I]eotaxin binding to human C-C chemokine receptor type 3 expre... | 15771462 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12166951 | 10.1021/jm0201767 | C-C chemokine receptor type 3 | 1 |
| 15771462 | 10.1021/jm049530m | C-C chemokine receptor type 3 | 1 |
Data from ChEMBL 36 via Core Engine